Description

Ethyl 6-(Trifluoromethyl)-1-benzothiophene-2-carboxylate is a high-purity, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the benzothiophene core and trifluoromethyl group impart desirable biological and physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to incorporate this privileged scaffold into new molecular entities.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in therapeutic areas targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functional additive in the synthesis of advanced organic electronic materials, such as organic semiconductors and light-emitting diodes (OLEDs).
• Chemical Biology Probe: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and as a fluorescent tag or molecular probe due to the benzothiophene fluorophore.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP guidelines for clinical trial materials.

Basic Information

Product Name	Ethyl 6-(Trifluoromethyl)-1-benzothiophene-2-carboxylate
CAS No.	1132650-51-1
Molecular Formula	C₁₂H₉F₃O₂S
Molecular Weight	274.26 g/mol
Synonyms	Ethyl 6-(trifluoromethyl)benzo[b]thiophene-2-carboxylate; 6-(Trifluoromethyl)-1-benzothiophene-2-carboxylic Acid Ethyl Ester; 1-Benzothiophene-2-carboxylic acid, 6-(trifluoromethyl)-, ethyl ester; Ethyl 6-trifluoromethyl-1-benzothiophene-2-carboxylate; 6-Trifluoromethylbenzothiophene-2-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 6-(Trifluoromethyl)-1-benzothiophene-2-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can adhere to relevant ISO and cGMP standards for advanced intermediates upon request, ensuring reliable supply for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.