Description

Rosiglitazone-D3 is a deuterium-labeled analog of the thiazolidinedione-class antidiabetic agent, Rosiglitazone. This stable isotope-labeled compound is essential for conducting precise pharmacokinetic and metabolic studies, providing critical data for drug development and safety assessments. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on diabetes research and analytical method development.

Application

• As an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the quantitative bioanalysis of Rosiglitazone.
• For conducting drug metabolism and pharmacokinetics (DMPK) studies to trace the absorption, distribution, metabolism, and excretion (ADME) pathways.
• Use in clinical research and therapeutic drug monitoring (TDM) to ensure accurate and reliable assay results.
• Application in forensic and anti-doping analysis for the definitive identification and quantification of the parent compound.
• As a critical reagent in the development and validation of regulatory-compliant analytical methods (e.g., FDA, EMA).
• For stable isotope dilution assays to achieve the highest accuracy in quantifying Rosiglitazone in complex biological matrices.

Basic Information

Product Name	Rosiglitazone-D3
CAS No.	1132641-22-5
Molecular Formula	C18H16D3N3O3S
Molecular Weight	360.44 g/mol
Synonyms	5-[[4-[2-(Methyl-D3-pyridinyl)amino]ethoxy]phenyl]methyl]-2,4-thiazolidinedione; Avandia-D3; BRL 49653-D3; (±)-Rosiglitazone-D3; Rosiglitazone (methyl-D3); Rosiglitazone-d3; 5-{4-[2-(N-Methyl-D3-pyridin-2-ylamino)ethoxy]benzyl}thiazolidine-2,4-dione
EINECS	Contact for details

Quality Control

Our Rosiglitazone-D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical and isotopic purity. Certificates of Analysis (COA) detailing batch-specific results for identity, purity, and isotopic enrichment are provided. We support compliance with cGMP and ICH guidelines for pharmaceutical reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (MS)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.