Description

Valganciclovir-D8 is a deuterated analog of the antiviral prodrug valganciclovir, specifically designed for use as an internal standard in analytical chemistry. This high-purity, isotopically labeled compound is essential for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and bioequivalence studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers who require precise and traceable measurement of valganciclovir and its metabolites.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of valganciclovir and ganciclovir in biological matrices (plasma, serum, urine) during bioanalytical method development and validation.
• Pharmacokinetic (PK) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and preclinical research.
• Drug Metabolism and Bioequivalence Research: Serves as a stable, non-interfering reference in studies comparing generic and brand-name formulations.
• Quality Control in Pharmaceutical Manufacturing: Used in analytical methods to monitor the purity and consistency of valganciclovir active pharmaceutical ingredient (API) and finished dosage forms.
• Forensic and Anti-Doping Analysis: Provides a reliable reference point in specialized testing protocols where precise measurement of antiviral agents is required.

Basic Information

Product Name	Valganciclovir-D8
CAS No.	1132088-63-1
Molecular Formula	C14H14D8N6O5
Molecular Weight	358.38 g/mol
Synonyms	L-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-methylbutyl ester-d8; (2S)-2-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-methylbutyl (2S)-2-amino-3-methylbutanoate-d8; Valganciclovir Deuterated; Valganciclovir-d8 Internal Standard; 9-[[2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine-d8 Valyl Ester
EINECS	Contact for details

Quality Control

Our Valganciclovir-D8 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), isotopic purity (by MS), and other critical parameters. We support compliance with GMP/GLP guidelines for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.