Description

Elvitegravir-D6 (Major) is a deuterated isotopologue of the HIV-1 integrase strand transfer inhibitor, Elvitegravir, where six hydrogen atoms are replaced by deuterium. This compound is a critical internal standard used in quantitative bioanalytical methods, ensuring the accuracy and reliability of pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical research and development laboratories, contract research organizations (CROs), and quality control units involved in the development and analysis of antiretroviral therapies.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the quantification of Elvitegravir in biological matrices (plasma, serum).
• Metabolite profiling and drug metabolism and pharmacokinetics (DMPK) studies to understand the disposition of Elvitegravir.
• Supporting bioequivalence and clinical trial studies for generic and novel HIV treatment formulations.
• Quality control and assurance in the manufacturing process of active pharmaceutical ingredients (APIs) and finished dosage forms.
• Use in forensic and anti-doping analysis for the precise detection of the parent drug.
• Fundamental research into the mechanism of action and resistance profiles of HIV-1 integrase inhibitors.

Basic Information

Product Name	Elvitegravir-D6 (Major)
CAS No.	1131640-69-1
Molecular Formula	C₂₃H₁₇D₆ClFNO₅
Molecular Weight	454.90 g/mol
Synonyms	6-(3-Chloro-2-fluorobenzyl)-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid-D6; GS-9137-D6; JTK-303-D6; Deuterated Elvitegravir; Elvitegravir (hexadeuterated); HIV-1 Integrase Inhibitor-D6; 1,4-Dihydro-1-(1-hydroxy-1-methylethyl)-6-(3-chloro-2-fluorobenzyl)-7-methoxy-4-oxoquinoline-3-carboxylic acid-D6
EINECS	Contact for details

Quality Control

Our Elvitegravir-D6 (Major) is manufactured under strict quality systems to ensure the highest standards of isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, chemical purity, isotopic enrichment, and residual solvents. We adhere to relevant ICH guidelines for analytical validation support.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D6)	≥98.0 atom % D
Chemical Purity (HPLC)	≥95.0%
Residual Solvents (GC)	Complies with ICH limits
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.