Description

Ciprofloxacin-D8 is a deuterated analog of the widely used fluoroquinolone antibiotic ciprofloxacin, specifically labeled with eight deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical measurements. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, clinical research, and forensic toxicology sectors who require precise quantification of ciprofloxacin in complex biological matrices.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in Liquid Chromatography-Tandem Mass Spectrometry for pharmacokinetic and bioequivalence studies.
• Pharmaceutical Research & Development: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion of ciprofloxacin.
• Clinical and Diagnostic Testing: Enables precise measurement of ciprofloxacin concentrations in patient plasma, serum, or urine for therapeutic drug monitoring.
• Forensic and Anti-Doping Analysis: Supports accurate detection and quantification of ciprofloxacin in forensic investigations and sports doping control.
• Environmental Analysis: Used in method development for detecting and quantifying trace levels of pharmaceutical residues in environmental water samples.
• Method Validation and Compliance: Critical for validating analytical methods according to FDA, EMA, and other regulatory guidelines in GLP/GMP environments.

Basic Information

Product Name	Ciprofloxacin-D8
CAS No.	1130050-35-9
Molecular Formula	C17H10D8FN3O3
Molecular Weight	335.36 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid-d8; 1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic Acid-d8; Ciprofloxacin (phenyl-d5, piperazine-d3); Ciprofloxacin-d8 (Major); Deuterated Ciprofloxacin; [2H8]-Ciprofloxacin
EINECS	Contact for details

Quality Control

Our Ciprofloxacin-D8 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity, suitable for the most demanding analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment (chemical and isotopic purity), assay, and identification. We support compliance with GLP and GMP standards, and specifications can be tailored to meet specific pharmacopeial or internal method requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Chemical Purity)
Isotopic Purity	≥ 98.0 atom % D
Isotopic Enrichment	≥ 99.0% (by MS)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.