Description

Paclitaxel-D5 is a deuterated analog of the potent anticancer agent Paclitaxel, where five hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical R&D, clinical research, and bioanalytical laboratories focused on oncology drug development and therapeutic monitoring.

Application

• Internal Standard for LC-MS/MS Analysis: Primary application for the precise quantification of Paclitaxel in biological matrices such as plasma, serum, and tissue homogenates.
• Pharmacokinetic and Bioavailability Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Metabolite Identification and Profiling: Aids in the detection and structural elucidation of Paclitaxel metabolites using high-resolution mass spectrometry.
• Drug Formulation and Stability Testing: Used as a reference compound in analytical method development and validation for quality control of pharmaceutical formulations.
• Biomarker Research: Supports quantitative proteomics and biomarker discovery efforts related to taxane-based chemotherapy responses.

Basic Information

Product Name	Paclitaxel-D5
CAS No.	1129540-33-5
Molecular Formula	C47H46D5NO14
Molecular Weight	858.90 g/mol (deuterated form)
Synonyms	Deuterated Paclitaxel (d5); Paclitaxel (phenyl-13C6, d5); Taxol-D5; NSC 125973-D5; (2α,4α,5β,7β,10β,13α)-4,10-Bis(acetyloxy)-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate-d5; 5-Deuterio Paclitaxel
EINECS	Contact for details

Quality Control

Our Paclitaxel-D5 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical results is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, controlled environment. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions should be avoided to maintain stability and isotopic integrity. Allow the vial to equilibrate to room temperature in a desiccator before opening.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.