Description

tert-Butyl 4-Chloro-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-1'-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a complex spirocyclic indole-piperidine scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of central nervous system (CNS) and oncological therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its privileged spirocyclic structure.
• API Development: Serves as a precursor in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs), particularly for complex small molecules.
• CNS Drug Discovery: The indole-piperidine core is a common pharmacophore in the development of compounds for neurological and psychiatric disorders.
• Oncology Research: Utilized in the creation of novel chemical entities for screening against cancer cell lines.
• Chemical Biology Probes: Acts as a scaffold for developing tool compounds to study biological processes and protein functions.
• Custom Synthesis: Supplied to contract research organizations (CROs) and CDMOs for client-specific synthesis projects.

Basic Information

Product Name	tert-Butyl 4-Chloro-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-1'-Carboxylate
CAS No.	1129432-44-5
Molecular Formula	C17H21ClN2O2
Molecular Weight	320.81 g/mol
Synonyms	1'-Boc-4-chloro-1,2-dihydrospiro[indole-3,4'-piperidine]; 4-Chloro-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylic acid tert-butyl ester; tert-Butyl 4-chloro-2,3-dihydro-1H-spiro[indole-3,4'-piperidine]-1'-carboxylate; 1,2-Dihydrospiro[indole-3,4'-piperidine]-1'-carboxylic acid, 4-chloro-, 1,1-dimethylethyl ester; 4-Chloro-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate tert-butyl ester; Boc-4-chloro-spiro[indoline-3,4'-piperidine]; 1129432-44-5; Spiro[indole-3,4'-piperidine] intermediate
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Chloro-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.