Description

Spiro[3H-Indole-3,4-Piperidine]-1-Carboxylic Acid, 1,2-Dihydro-4-(Trifluoromethyl)-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic indole-piperidine scaffold. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel drug candidates targeting central nervous system (CNS) disorders and other therapeutic areas. It is primarily sought by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of innovative small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those with spirocyclic architectures.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs for CNS-targeted therapies.
• Protease Inhibitor Development: The structural motif is relevant for the development of inhibitors for various enzymatic targets.
• Chemical Biology Probes: Serves as a scaffold for creating molecular probes to study biological pathways and protein function.
• Custom Synthesis: Employed by fine chemical suppliers for the contract manufacturing of complex, non-commercial molecules for client R&D.
• Academic Research: Utilized in university and institutional labs for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	Spiro[3H-Indole-3,4-Piperidine]-1-Carboxylic Acid, 1,2-Dihydro-4-(Trifluoromethyl)-, 1,1-Dimethylethyl Ester
CAS No.	1129421-52-8
Molecular Formula	C19H23F3N2O2
Molecular Weight	368.40 g/mol
Synonyms	tert-Butyl 1,2-dihydro-4-(trifluoromethyl)spiro[3H-indole-3,4'-piperidine]-1'-carboxylate; 1,1-Dimethylethyl 1,2-dihydro-4-(trifluoromethyl)spiro[3H-indole-3,4'-piperidine]-1'-carboxylate; 4-(Trifluoromethyl)spiro[indoline-3,4'-piperidine]-1'-carboxylic acid tert-butyl ester; Spiro[indoline-3,4'-piperidine]-1'-carboxylic acid, 1,2-dihydro-4-(trifluoromethyl)-, 1,1-dimethylethyl ester; 1129421-52-8; BOC-protected 4-(trifluoromethyl)spiro[indoline-3,4'-piperidine]
EINECS	Contact for details

Quality Control

Our Spiro[3H-Indole-3,4-Piperidine]-1-Carboxylic Acid, 1,2-Dihydro-4-(Trifluoromethyl)-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.