Description

tert-Butyl 5-(Trifluoromethyl)-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-1'-Carboxylate CAS NO 1128150-05-9 is a high-value, advanced pharmaceutical intermediate featuring a complex spirocyclic indole-piperidine scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting central nervous system (CNS) disorders and other therapeutic areas. Its unique structure, incorporating a trifluoromethyl group, makes it an essential building block for pharmaceutical companies and contract research organizations (CROs) engaged in drug discovery programs.

Application

• Key Intermediate in Drug Discovery: Serves as a privileged scaffold for synthesizing potential drug candidates, especially in neuroscience and oncology research.
• Medicinal Chemistry Building Block: Used for structure-activity relationship (SAR) studies and lead optimization due to its spirocyclic and trifluoromethyl motifs.
• Synthesis of Biologically Active Compounds: Integral in creating molecules with potential activity as kinase inhibitors, receptor modulators, or enzyme inhibitors.
• Contract Research & Development (CRO/CDMO): Supplied to research facilities for custom synthesis and preclinical development of new chemical entities (NCEs).
• Academic Research: Utilized in university and institutional labs for studying novel heterocyclic chemistry and pharmacological properties.
• Process Chemistry Development: Acts as a starting material or intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.

Basic Information

Product Name	tert-Butyl 5-(Trifluoromethyl)-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-1'-Carboxylate
CAS No.	1128150-05-9
Molecular Formula	C18H21F3N2O2
Molecular Weight	354.37 g/mol
Synonyms	1'-Boc-5-(trifluoromethyl)spiro[indoline-3,4'-piperidine]; tert-Butyl 5-(trifluoromethyl)-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate; 5-(Trifluoromethyl)spiro[indoline-3,4'-piperidine]-1'-carboxylic acid tert-butyl ester; 1,2-Dihydrospiro[indole-3,4'-piperidine]-1'-carboxylic acid, 5-(trifluoromethyl)-, 1,1-dimethylethyl ester; 1'-Boc-5-CF3-spiro[indoline-3,4'-piperidine]; Boc-5-trifluoromethyl-spiro[indoline-3,4'-piperidine]; 1128150-05-9; Spiro[indoline-3,4'-piperidine] intermediate
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-(Trifluoromethyl)-1,2-Dihydrospiro[Indole-3,4'-Piperidine]-1'-Carboxylate is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture uptake. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.