Description

tert-Butyl 7-Bromospiro[Indoline-3,4'-Piperidine]-1'-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a complex spirocyclic indoline-piperidine scaffold. This compound is critical for research and development in medicinal chemistry, serving as a versatile building block for the synthesis of novel bioactive molecules. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) focused on developing new therapeutic agents, particularly in central nervous system (CNS) and oncology drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potential drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of novel bifunctional degraders.
• Chemical Biology Probes: Utilized in the development of tool compounds for investigating biological targets and signaling pathways.
• Custom Synthesis & Scale-Up: Supplied for custom manufacturing projects, from gram-scale research to kilogram-scale process development.

Basic Information

Product Name	tert-Butyl 7-Bromospiro[Indoline-3,4'-Piperidine]-1'-Carboxylate
CAS No.	1128133-41-4
Molecular Formula	C17H23BrN2O2
Molecular Weight	367.28 g/mol
Synonyms	1'-Boc-7-bromospiro[indoline-3,4'-piperidine]; 7-Bromo-1'-(tert-butoxycarbonyl)spiro[indoline-3,4'-piperidine]; tert-Butyl 7-bromo-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate; 7-Bromospiro[indoline-3,4'-piperidine]-1'-carboxylic acid tert-butyl ester; 1,1-Dimethylethyl 7-bromo-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate; 7-Bromo-1'-(tert-butyloxycarbonyl)spiro[indoline-3,4'-piperidine]; Boc-7-Bromo-spiro[indoline-3,4'-piperidine]; 1128133-41-4
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-Bromospiro[Indoline-3,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.