Description

Galanthamine-o-(Methyl-D3)-n-(Methyl-D3) is a deuterated isotopologue of the alkaloid galantamine, specifically labeled with deuterium atoms on both methyl groups. This compound is a critical reference standard and labeled intermediate for advanced pharmaceutical research and development, particularly in pharmacokinetic and metabolic studies. It is essential for scientists in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors who require high-purity, stable isotopically labeled materials for mass spectrometry-based assays, drug metabolism and pharmacokinetics (DMPK) investigations, and the development of novel therapeutics targeting neurological conditions.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a crucial quantitative internal standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods for the accurate bioanalysis of galantamine in biological matrices like plasma and tissue.
• Drug Metabolism Studies (DMPK): Used as a tracer to elucidate the metabolic pathways, bioavailability, and excretion profiles of galantamine, aiding in the understanding of its pharmacokinetic behavior.
• Pharmaceutical Reference Standard: Employed as a certified reference material (CRM) for method development, validation, and quality control in analytical laboratories to ensure accuracy and regulatory compliance.
• Isotope Dilution Mass Spectrometry (IDMS): A key component in high-precision IDMS techniques, which are considered a gold standard for achieving definitive measurement results in clinical and forensic toxicology.
• Neurological Research: As a labeled analog of a clinically used acetylcholinesterase inhibitor, it facilitates advanced research into the mechanisms of action and distribution of cholinergic therapies within the central nervous system.
• Synthesis of Labeled Drug Candidates: Acts as a sophisticated building block for the chemical synthesis of more complex deuterated drug candidates for next-generation clinical trials.

Basic Information

Product Name	Galanthamine-o-(Methyl-D3)-n-(Methyl-D3)
CAS No.	1128109-00-1
Molecular Formula	C17H21D6NO3
Molecular Weight	301.44 g/mol
Synonyms	Galanthamine-d6; Galantamine-d6; (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-d3-11-methyl-d3-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol; 11,17-O-Dimethyl-d6-galantamine; Deuterated Galantamine; Galantamine (methyl-d3) ether; N-Methyl-d3 Galantamine O-methyl-d3 ether; Lycoremine-d6
EINECS	Contact for details

Quality Control

Every batch of Galanthamine-o-(Methyl-D3)-n-(Methyl-D3) is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including HPLC for chemical purity, NMR and MS for structural and isotopic confirmation, and determination of residual solvents. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the exact specifications for your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., argon or nitrogen) when the container is opened and resealed to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium incorporation)	≥ 99.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.