Description

Doxazosin-D8 (Piperazine-D8) is a deuterium-labeled analog of the α-1 adrenergic receptor antagonist doxazosin, where eight hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring high accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical material for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on drug development and regulatory compliance.

Application

• Internal Standard for LC-MS/MS: Serves as a crucial internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the precise quantification of doxazosin in biological matrices like plasma, serum, and urine.
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Bioanalytical Method Development & Validation: Used to develop and validate robust, GLP-compliant analytical methods for regulatory submissions to agencies like the FDA and EMA.
• Drug Impurity Profiling & Degradation Studies: Assists in identifying and quantifying potential deuterated impurities or degradation products in pharmaceutical formulations.
• Stable Isotope Dilution Assays: Fundamental for high-precision assays where the labeled compound compensates for sample preparation and ionization variability in mass spectrometry.

Basic Information

Product Name	Doxazosin-D8 (Piperazine-D8)
CAS No.	1126848-44-9
Molecular Formula	C23H17D8N5O5
Molecular Weight	459.51 g/mol (approximate)
Synonyms	Doxazosin-d8; [2H8]-Doxazosin; Doxazosin (piperazine-d8); 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-([(2,3,4,5,6,7,8,8-2H8]1,4-benzodioxan-2-yl)carbonyl)piperazine; Deuterated Doxazosin; Doxazosin Internal Standard; Doxazosin Stable Isotope
EINECS	Contact for details

Quality Control

Our Doxazosin-D8 (Piperazine-D8) is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay (by HPLC), isotopic enrichment (by NMR or MS), and related substance profiles. We adhere to relevant industry standards for stable isotope-labeled compounds to guarantee reliable performance and traceability in your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.