Description

(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-n-Methyl-1-Naphthalenamine-D3 is a deuterated isotopologue of a key pharmaceutical intermediate. This compound is specifically designed for use in advanced research and development, offering enhanced metabolic stability and traceability in pharmacokinetic and metabolic studies. It is an essential building block for medicinal chemists and analytical scientists in the pharmaceutical and biotechnology sectors.

Application

• Primary use as a deuterium-labeled internal standard for the precise quantification of its non-deuterated counterpart in bioanalytical methods (LC-MS/MS).
• Critical intermediate in the research and development of novel therapeutic agents targeting central nervous system (CNS) disorders.
• Tool compound for conducting drug metabolism and pharmacokinetics (DMPK) studies to investigate metabolic pathways.
• Used in the synthesis of radiolabeled or isotopically labeled probes for advanced biomedical research.
• Reference material in pharmaceutical quality control laboratories for method development and validation.
• Building block for academic research in organic chemistry and pharmacology focused on tetralin-based structures.

Basic Information

Product Name	(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-n-Methyl-1-Naphthalenamine-D3
CAS No.	1126784-49-3
Molecular Formula	C₁₇H₁₄D₃Cl₂N
Molecular Weight	306.22 g/mol (deuterated form)
Synonyms	(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine-d3; N-Methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine-d3 (1S,4S)-; Deuterated Sertraline Intermediate-d3; (1S,4S)-1-Amino-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalene-d3; cis-(+)-Sertraline precursor-d3; Zoloft Intermediate-d3; Tetralinamine derivative-d3
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality management systems to ensure isotopic purity and chemical integrity. Each batch is characterized by advanced spectroscopic techniques (NMR, MS) and chromatographic methods (HPLC, GC) to confirm identity, chemical purity, and deuterium incorporation. Certificates of Analysis (COA) detailing isotopic enrichment (D-content), chemical purity, and analytical data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Incorporation (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.