Description

(R)-5-Bromo-3-(n-Methylpyrrolidin-2-Ylmethyl-D5)-1H-Indole is a high-purity, deuterated indole derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical labeled intermediate or reference standard for metabolic and pharmacokinetic studies, enabling precise tracking within biological systems. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) engaged in the discovery and development of novel therapeutics, particularly in neuroscience and oncology.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of deuterated drug candidates, potentially enhancing metabolic stability and pharmacokinetic profiles.
• Metabolic Tracer: Used in drug metabolism and pharmacokinetics (DMPK) studies to investigate the absorption, distribution, metabolism, and excretion (ADME) of lead compounds.
• Internal Standard: Serves as a deuterated internal standard in quantitative bioanalytical methods (LC-MS/MS) for accurate drug quantification in biological matrices.
• Neurological Research: As a structurally specific indole derivative, it is valuable for researching ligands targeting serotonin or other neurological receptors.
• Isotope Labeling Studies: Facilitates mechanistic studies in medicinal chemistry, helping to elucidate reaction pathways and metabolic soft spots.
• Reference Material: Provides a certified standard for quality control and method validation in analytical laboratories.

Basic Information

Product Name	(R)-5-Bromo-3-(n-Methylpyrrolidin-2-Ylmethyl-D5)-1H-Indole
CAS No.	1126745-77-4
Molecular Formula	C₁₄H₁₃D₅BrN₂
Molecular Weight	Contact for details
Synonyms	1H-Indole, 5-bromo-3-[(2R)-1-methyl-2-pyrrolidinyl-D5-methyl]-
(R)-5-Bromo-3-((1-methylpyrrolidin-2-yl-D5)methyl)-1H-indole
5-Bromo-3-[(2R)-1-methyl-2-pyrrolidinyl-D5-methyl]-1H-indole
Deuterated (R)-5-Bromo-3-(1-methylpyrrolidin-2-ylmethyl)-1H-indole
(R)-5-Bromo-3-(N-Methylpyrrolidin-2-ylmethyl-d5)-1H-indole
1126745-77-4
Deuterium-labeled indole derivative
EINECS	Contact for details

Quality Control

Our (R)-5-Bromo-3-(n-Methylpyrrolidin-2-Ylmethyl-D5)-1H-Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation and deuterium incorporation, to ensure it meets the exacting standards required for pharmaceutical research. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and isotopic enrichment are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Deuterium Incorporation (NMR/MS)	≥ 95 atom % D
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.