Description

Sunitinib-D10 CAS NO 1126721-82-1 is a deuterated analog of the multi-targeted receptor tyrosine kinase inhibitor Sunitinib, where ten hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is essential for high-precision quantitative analysis in pharmaceutical research and development. It is primarily used by analytical chemists and researchers in pharmaceutical, contract research, and academic laboratories for use as an internal standard in mass spectrometry-based assays.

Application

• Internal Standard for LC-MS/MS: Enables accurate quantification of Sunitinib and its metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Pharmacokinetic (PK) and Pharmacodynamic (PD) Studies: Critical for determining drug absorption, distribution, metabolism, and excretion (ADME) profiles during preclinical and clinical development.
• Bioanalytical Method Development and Validation: Serves as a key component in establishing robust, sensitive, and regulatory-compliant analytical methods.
• Drug Metabolism Research: Used to study metabolic pathways and identify metabolites without interference from endogenous compounds.
• Therapeutic Drug Monitoring (TDM): Facilitates precise measurement of drug concentrations in patient samples to optimize dosing regimens.
• Quality Control in Manufacturing: Can be employed in impurity profiling and stability testing of the active pharmaceutical ingredient (API).

Basic Information

Product Name	Sunitinib-D10
CAS No.	1126721-82-1
Molecular Formula	C₂₂H₁₇D₁₀FN₄O₂
Molecular Weight	407.52 g/mol
Synonyms	Sunitinib-d10; Deutorated Sunitinib; N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide-d10; SU11248-d10; Sutent-d10 (labeled analog); (Z)-N-[2-(Diethylamino)ethyl]-5-[(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide-d10
EINECS	Contact for details

Quality Control

Our Sunitinib-D10 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.