Description

5-[(Z)-(5-Fluoro-2-Oxo-1H-Indol-3-Ylidene)Methyl]-2,4-Dimethyl-n-[1,1,2,2-Tetradeuterio-2-(Diethylamino)Ethyl]-1H-Pyrrole-3-Carboxamide is a deuterated indole-pyrrole derivative of significant interest in advanced pharmaceutical research and development. This compound matters as a deuterium-labeled analog, offering enhanced metabolic stability and pharmacokinetic properties for investigative purposes. It is primarily needed by pharmaceutical R&D teams and contract research organizations (CROs) engaged in the development of novel therapeutic agents, particularly in oncology and neurological disorders.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for method development, validation, and quality control in drug substance and product analysis.
• Deuterated Drug Discovery: Used as a key intermediate or active pharmaceutical ingredient (API) analog in the research of deuterium-enabled drugs, leveraging the deuterium kinetic isotope effect (DKIE).
• Metabolic and Pharmacokinetic (PK/PD) Studies: Employed as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and LC-MS/MS bioanalytical assays for precise quantification in biological matrices.
• Mechanism of Action (MoA) Research: Utilized in biochemical and cellular assays to study drug-target interactions and signaling pathways with improved metabolic stability.
• Preclinical Development: Supports toxicology, formulation, and stability studies for new chemical entities (NCEs) containing this structural scaffold.
• Academic and Institutional Research: Facilitates fundamental chemical and biological research in medicinal chemistry and chemical biology at universities and research institutes.

Basic Information

Product Name	5-[(Z)-(5-Fluoro-2-Oxo-1H-Indol-3-Ylidene)Methyl]-2,4-Dimethyl-n-[1,1,2,2-Tetradeuterio-2-(Diethylamino)Ethyl]-1H-Pyrrole-3-Carboxamide
CAS No.	1126721-79-6
Molecular Formula	C22H24D4FN4O2
Molecular Weight	396.50 g/mol (deuterated form)
Synonyms	5-[(Z)-(5-Fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, N-[1,1,2,2-Tetradeuterio-2-(diethylamino)ethyl] derivative; Deuterated Sunitinib-d4 impurity/analog; (Z)-5-[(5-Fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(diethylamino)ethyl]-1H-pyrrole-3-carboxamide-d4; N-[2-(Diethylamino-d4)ethyl]-5-[(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide; Sunitinib-d4 related compound; SU11248-d4; 5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(N,N-diethylamino)ethyl]-1H-pyrrole-3-carboxamide-d4.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical development. We provide comprehensive analytical data including HPLC purity, isotopic enrichment (D-content), and structural confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing batch-specific results are available upon request. Production and quality processes are designed to meet the stringent requirements for reference standards and advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange solid powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D (by MS)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.