Description

Gabapentin-D10 is a deuterated internal standard of the pharmaceutical compound Gabapentin, specifically designed for analytical applications. This stable isotope-labeled compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses. It is primarily used by researchers and quality control laboratories in the pharmaceutical, forensic, and clinical diagnostics industries for method development, validation, and routine testing.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard for the precise measurement of Gabapentin levels in biological matrices (e.g., plasma, serum, urine) using LC-MS/MS.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion in clinical and preclinical research.
• Therapeutic Drug Monitoring (TDM): Used in clinical laboratories to ensure accurate dosing by measuring patient blood concentrations of Gabapentin.
• Forensic and Toxicology Testing: Provides a reliable reference for confirming and quantifying Gabapentin in forensic investigations and substance abuse screenings.
• Pharmaceutical Quality Control: Supports impurity profiling, assay development, and stability testing of Gabapentin drug substances and products.
• Metabolite Identification Studies: Aids in the identification and quantification of Gabapentin metabolites in complex biological samples.

Basic Information

Product Name	Gabapentin-D10
CAS No.	1126623-20-8
Molecular Formula	C9H7D10NO2
Molecular Weight	185.30 g/mol
Synonyms	1-(Aminomethyl)cyclohexaneacetic acid-2,2,3,3,4,4,5,5,6,6-d10; Gabapentin (phenyl-d10); Gabapentin-d10; [2H10]-Gabapentin; 2-[1-(Aminomethyl)cyclohexyl]acetic-2,2,3,3,4,4,5,5,6,6-d10 acid; GPB-d10; Neurontin-d10 (labeled analogue)
EINECS	Contact for details

Quality Control

Every batch of Gabapentin-D10 is produced and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the isotopic enrichment (typically ≥98 atom % D), chemical purity (≥95%), and results of identity and purity tests. Our quality system is designed to meet the stringent requirements of analytical reference standard users.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (Atom % D)	≥ 98%
Chemical Purity (by HPLC)	≥ 95%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.