Description

Piperazine-3,3,5,5-D4-n-T-Boc CAS NO 1126621-87-1 is a deuterium-labeled derivative of N-tert-butoxycarbonyl (Boc)-protected piperazine, serving as a critical stable isotope-labeled building block. This compound is essential for advanced research and development, providing a non-radioactive isotopic tracer for mechanistic studies, metabolic pathway analysis, and quantitative mass spectrometry. It is primarily utilized by pharmaceutical researchers, analytical chemists, and contract research organizations (CROs) engaged in drug discovery, development of deuterated active pharmaceutical ingredients (APIs), and high-precision bioanalytical method validation.

Application

• Deuterated API Synthesis: A key precursor in the development of deuterium-labeled pharmaceutical compounds for improved metabolic stability and pharmacokinetic profiling.
• Internal Standard for LC-MS/MS: Used as a high-purity, isotopically labeled internal standard for accurate quantification of piperazine-based compounds or metabolites in complex biological matrices.
• Mechanistic & Metabolic Studies: Enables tracing and identification of metabolic pathways and reaction mechanisms in preclinical and clinical research without radioactive hazards.
• Proteomics & Biomarker Research: Facilitates stable isotope labeling strategies in quantitative proteomics for biomarker discovery and validation.
• NMR Spectroscopy: Serves as a valuable tool in nuclear magnetic resonance (NMR) spectroscopy for structural elucidation and dynamic studies.
• Chemical Reference Standard: Provides a certified reference material for quality control and regulatory compliance in analytical laboratories.

Basic Information

Product Name	Piperazine-3,3,5,5-D4-n-T-Boc
CAS No.	1126621-87-1
Molecular Formula	C9H14D4N2O2
Molecular Weight	190.27 g/mol (for deuterated form)
Synonyms	1-Boc-piperazine-3,3,5,5-d4; N-Boc-piperazine-3,3,5,5-d4; 1-(tert-Butoxycarbonyl)piperazine-3,3,5,5-d4; tert-Butyl piperazine-1-carboxylate-3,3,5,5-d4; 4-(tert-Butoxycarbonyl)piperazine-3,3,5,5-d4; BOC-Piperazine-d4; Deuterated Boc-Piperazine; Piperazine-1-carboxylic acid tert-butyl ester-3,3,5,5-d4
EINECS	Contact for details

Quality Control

Every batch of Piperazine-3,3,5,5-D4-n-T-Boc is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and isotopic enrichment meet the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting results from NMR (¹H, ¹³C), HPLC/LC-MS, and Isotopic Enrichment Analysis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.