Description

Dalbavancin-D6 is a stable, deuterium-labeled isotopic analog of the lipoglycopeptide antibiotic dalbavancin, widely used as an internal standard in quantitative bioanalytical assays. It enables highly accurate and precise measurement of dalbavancin concentrations in biological matrices—critical for pharmacokinetic, toxicokinetic, and clinical trial studies. This compound is essential for pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory-compliant bioanalytical service providers conducting LC-MS/MS-based quantification. Dalbavancin-D6 CAS NO 1126461-54-8 is manufactured under stringent quality controls to ensure isotopic purity and batch-to-batch consistency.

Application

• Internal standard for LC-MS/MS quantification of dalbavancin in human plasma, serum, and tissue homogenates
• Reference material in method validation studies per FDA, EMA, and ICH M10 guidelines
• Calibration standard preparation for high-sensitivity bioanalysis in Phase I–IV clinical trials
• Quality control spike-in for assay accuracy assessment in regulated GLP and GCP environments
• Stability-indicating method development for dalbavancin degradation product profiling
• Supporting analytical transfer between laboratories during global drug development programs
• Use in preclinical ADME (Absorption, Distribution, Metabolism, Excretion) studies in animal models
• Reference compound for certifying reference materials (CRM) and secondary standards

Basic Information

Product Name	Dalbavancin-D6
CAS No.	1126461-54-8
Molecular Formula	C97H131D6N11O32
Molecular Weight	2025.25 g/mol
Synonyms	Dalbavancin-d6; Dalbavancin-6D; (3R,4S,5R,6R)-6-[(2S,3R,4S,5S,6R)-4-[(2S,3R,4S,5S,6R)-4-[(2S,3R,4S,5S,6R)-4-[(2S,3R,4S,5S,6R)-4-Amino-3,5-dihydroxy-6-methyltetrahydropyran-2-yl]oxy-3,5-dihydroxy-6-methyltetrahydropyran-2-yl]oxy-3,5-dihydroxy-6-methyltetrahydropyran-2-yl]oxy-5-hydroxy-3-(hydroxymethyl)tetrahydropyran-2-yl]oxy-3-(carbamoylmethyl)-5-[(2R,3S,4R,5R,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-4-methoxy-2-methyl-1H-pyrrolizine-1-carboxamide; N-[2-[[[3-(acetylamino)-2-hydroxypropyl]amino]carbonyl]phenyl]-N-(2-amino-2-deoxy-β-D-glucopyranosyl)-L-asparagine-d6; Dalbavancin-6-d; [D6]-Dalbavancin; Dalbavancin deuterated analog
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch is verified for isotopic enrichment (>98% D-incorporation at six designated positions), chemical purity (≥98.5% by HPLC), identity (IR, NMR, and HRMS), and absence of microbial contamination. Testing adheres to ICH Q5, Q7, and Q11 guidelines, and manufacturing follows cGMP principles appropriate for reference standards used in regulated bioanalysis.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (argon or nitrogen) to prevent degradation. Due to its hygroscopic nature, minimize exposure to ambient humidity; allow the vial to equilibrate to room temperature before opening. Keep away from strong oxidizing agents and organic solvents.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (IR)	Conforms to reference spectrum
Identification (HRMS)	m/z matches theoretical [M+H]+ for C97H131D6N11O32
Isotopic Purity (by 1H-NMR)	≥98% D-incorporation at six labeled positions
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	≤1.0% total impurities
Residual Solvents (GC)	Meets ICH Q3C limits
Water Content (Karl Fischer)	≤5.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.