Description

1-Chloro-5-Fluoro-4-Iodo-2-Methylbenzene is a high-purity halogenated benzene derivative, a key building block in advanced organic synthesis. Its unique multi-halogen substitution pattern makes it an invaluable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research institutions and pharmaceutical companies for the development of active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting complex heterocycles and fluorinated bioactive molecules.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and pesticides, where the iodine and fluorine atoms can be leveraged for further functionalization.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Reference Standard: Supplied as a high-purity analytical standard for method development and quality control in analytical laboratories.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form complex biaryl structures.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for the systematic exploration of structure-activity relationships (SAR) in various chemical series.

Basic Information

Product Name	1-Chloro-5-Fluoro-4-Iodo-2-Methylbenzene
CAS No.	1126424-32-5
Molecular Formula	C7H5ClFI
Molecular Weight	269.47 g/mol
Synonyms	4-Chloro-2-Fluoro-5-Iodotoluene; 2-Methyl-1-chloro-5-fluoro-4-iodobenzene; 5-Fluoro-4-iodo-2-methylchlorobenzene; 1-Chloro-5-fluoro-4-iodo-o-xylene; Benzene, 1-chloro-5-fluoro-4-iodo-2-methyl-; Toluene, 4-chloro-2-fluoro-5-iodo-
EINECS	Contact for details

Quality Control

Our 1-Chloro-5-Fluoro-4-Iodo-2-Methylbenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. Due to its light-sensitive nature, containers should be amber glass or opaque to prevent photodegradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.