Description

3-Chloro-2-Fluorobenzenethiol is a specialized organosulfur building block featuring a thiol group ortho to a fluorine atom and meta to a chlorine substituent. This unique structure makes it a valuable intermediate for synthesizing complex molecules in advanced research and development. It is primarily sought after by pharmaceutical and agrochemical R&D teams for creating novel active ingredients, ligands, and functional materials where precise halogen and sulfur placement is critical.

Application

• Pharmaceutical Intermediate: Key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require halogenated aromatic thiol motifs.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of novel polymers, liquid crystals, and electronic materials with specific sulfur-based functionalities.
• Custom Synthesis and Contract Manufacturing: A critical starting material for fine chemical manufacturers offering bespoke synthesis services to the life sciences industry.

Basic Information

Product Name	3-Chloro-2-Fluorobenzenethiol
CAS No.	1121585-29-2
Molecular Formula	C6H4ClFS
Molecular Weight	162.61 g/mol
Synonyms	2-Fluoro-3-chlorobenzenethiol; 3-Chloro-2-fluorothiophenol; 2-Fluoro-3-chlorothiophenol; 1-Chloro-2-fluoro-3-mercaptobenzene; Benzenethiol, 3-chloro-2-fluoro-; (3-Chloro-2-fluorophenyl)thiol
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-Fluorobenzenethiol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles against agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C) under an inert atmosphere (e.g., nitrogen) to prevent oxidation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.