Description

Desmosine-D4 is a stable isotope-labeled analog of desmosine, a unique cross-linking amino acid specific to mature elastin. This compound is an essential internal standard for the precise quantification of elastin degradation products in biological matrices, enabling accurate biomarker analysis. It is primarily utilized by researchers and diagnostic laboratories in the fields of pulmonary medicine, cardiovascular research, and connective tissue disorder studies.

Application

• Biomarker Quantification: Serves as an internal standard in LC-MS/MS methods for measuring free desmosine and isodesmosine in urine, serum, or plasma as biomarkers of elastin turnover.
• Pulmonary Disease Research: Critical for studies on chronic obstructive pulmonary disease (COPD), emphysema, and cystic fibrosis to assess disease progression and therapeutic efficacy.
• Cardiovascular Research: Used in research on abdominal aortic aneurysms (AAA), atherosclerosis, and other vascular diseases involving elastin degradation.
• Connective Tissue Disorder Analysis: Applied in the investigation of genetic disorders like cutis laxa and Marfan syndrome.
• Pharmacokinetic/Pharmacodynamic Studies: Employed in drug development for compounds targeting elastase activity or aiming to protect elastin fibers.
• Method Development and Validation: Essential for developing and validating highly sensitive and specific analytical assays in clinical and research settings.
• Quality Control in Diagnostic Kits: Used as a reference material in the production and QC of commercial diagnostic kits for elastin-derived peptides.

Basic Information

Product Name	Desmosine-D4
CAS No.	1119270-58-4
Molecular Formula	C24H36D4N5O8
Molecular Weight	526.60 g/mol
Synonyms	Deuterated Desmosine; [D4]-Desmosine; Desmosine (D4); 4,5-Dihydro-5,5-bis(3-amino-3-carboxypropyl)-1H-imidazole-4-propanoic acid-D4; (2S)-2-Amino-5-[(4R)-4-amino-4-carboxybutyl]-1-(3-amino-3-carboxypropyl)-3,5-dihydro-4H-imidazole-4-carboxylic acid-D4; Isotopically Labeled Desmosine; Elastin Cross-link Amino Acid-D4; Internal Standard for Desmosine
EINECS	Contact for details

Quality Control

Our Desmosine-D4 is manufactured under strict quality protocols to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and analytical data (HPLC, MS, NMR) is provided to guarantee consistency and reliability for your research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Purity (HPLC)	≥ 95%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in water, dilute acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.