Description

1-(5-Bromo-4-Nitroindoline)Ethanone is a high-purity, advanced pharmaceutical intermediate characterized by its specific bromo-nitroindoline structure. This compound is critical for medicinal chemistry research and development, serving as a key building block in the synthesis of novel, biologically active molecules. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, particularly within oncology and CNS drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of new chemical entities.
• Organic Synthesis Building Block: Employed in cross-coupling reactions and functional group transformations to create diverse chemical libraries.
• Proteolysis-Targeting Chimera (PROTAC) Development: Serves as a component in the linker or warhead design for targeted protein degradation therapeutics.
• Agrochemical Research: Investigated as an intermediate for developing new crop protection agents with novel modes of action.

Basic Information

Product Name	1-(5-Bromo-4-Nitroindoline)Ethanone
CAS No.	1116339-78-6
Molecular Formula	C10H9BrN2O3
Molecular Weight	285.10 g/mol
Synonyms	1-(5-Bromo-4-nitro-2,3-dihydro-1H-indol-1-yl)ethanone; 1-Acetyl-5-bromo-4-nitroindoline; 5-Bromo-4-nitro-1-indolinyl methyl ketone; Ethanone, 1-(5-bromo-4-nitro-2,3-dihydro-1H-indol-1-yl)-; 1116339-78-6; 5-Bromo-4-nitroindoline-1-acetone
EINECS	Contact for details

Quality Control

Our 1-(5-Bromo-4-Nitroindoline)Ethanone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP starting material requirements. Specifications are aligned with standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive). Keep away from incompatible materials such as strong acids and strong oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.