Description

Morpholine-2,2,3,3,5,5,6,6-D8 Hydrochloride CAS NO 1107650-56-5 is a deuterated derivative of morpholine hydrochloride, where eight hydrogen atoms are replaced by deuterium, a stable isotope of hydrogen. This deuteration is critical for applications requiring reduced metabolic lability and enhanced analytical precision, such as in the development of internal standards for mass spectrometry. It is an essential building block for researchers and manufacturers in the pharmaceutical and analytical chemistry sectors who require high-purity, isotopically labeled compounds for advanced studies.

Application

• As a deuterated internal standard for the accurate quantification of morpholine and its derivatives in complex biological matrices via LC-MS/MS and GC-MS.
• In pharmaceutical research and development for pharmacokinetic (PK) and metabolic stability studies of drug candidates containing the morpholine moiety.
• For use in NMR spectroscopy as a solvent or reagent where deuterium labeling is necessary to avoid signal interference from protons.
• In the synthesis of deuterated active pharmaceutical ingredients (APIs) and advanced intermediates for clinical trials and regulatory submissions.
• As a key reagent in mechanistic studies and reaction pathway elucidation in organic and medicinal chemistry.
• For forensic and environmental analysis where isotopically labeled compounds are used as tracers or standards.

Basic Information

Product Name	Morpholine-2,2,3,3,5,5,6,6-D8 Hydrochloride
CAS No.	1107650-56-5
Molecular Formula	C4D8H2NO.ClH
Molecular Weight	117.62 g/mol (for D8 form)
Synonyms	Perdeuterated Morpholine Hydrochloride; Morpholine-d8 Hydrochloride; Tetrahydro-1,4-oxazine-2,2,3,3,5,5,6,6-d8 hydrochloride; 1,4-Oxazinane-d8 hydrochloride; Deuterated Morpholine HCl; D8-Morpholine HCl; 2,2,3,3,5,5,6,6-Octadeuteromorpholine hydrochloride
EINECS	Contact for details

Quality Control

Our Morpholine-2,2,3,3,5,5,6,6-D8 Hydrochloride is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (D-content), chemical purity, and identification. We adhere to cGMP principles for advanced intermediates and provide traceable documentation to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment (D-content)	≥98 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.