Description

8-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,4-Dioxaspiro[4.5]Decane is a high-value, protected boronic ester building block essential for modern synthetic chemistry. This compound is a critical intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex carbon-carbon bonds. It is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates via palladium-catalyzed cross-coupling.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific spirocyclic architectures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology & Medicinal Chemistry: Enables the late-stage functionalization and diversification of complex molecules in probe and library synthesis.
• Academic & Industrial R&D: A versatile reagent for methodological development and exploring new synthetic routes in organic chemistry laboratories.
• Ligand and Catalyst Development: Can be incorporated into novel chiral or functional ligands for asymmetric catalysis.

Basic Information

Product Name	8-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,4-Dioxaspiro[4.5]Decane
CAS No.	1106871-37-7
Molecular Formula	C15H27BO4
Molecular Weight	282.18 g/mol
Synonyms	1,4-Dioxaspiro[4.5]decane-8-boronic acid pinacol ester; 8-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro[4.5]decane; 8-Boronic acid, 1,4-dioxaspiro[4.5]decane-, pinacol ester; 1,4-Dioxaspiro[4.5]dec-8-ylboronic acid pinacol ester; 8-(Pinacolatoboryl)-1,4-dioxaspiro[4.5]decane; Cyclohexanone ethylene ketal-4-boronic acid pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dioxaspiro[4.5]decane (alternate numbering).
EINECS	Contact for details

Quality Control

Every batch of 8-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,4-Dioxaspiro[4.5]Decane is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including NMR (1H, 13C, 11B), HPLC, and GC, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C or as specified on the label. This material is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air and moisture must be avoided to maintain purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥95.0% (Typical 97-99%)
Purity (GC)	≥95.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.