Description

4,6-Difluoro-1-Methyl-1H-Indole is a high-purity fluorinated indole derivative, a critical building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of pharmaceuticals and agrochemicals, where its unique fluorine substitution pattern enables precise modulation of biological activity and physicochemical properties. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and pesticides, leveraging fluorine's ability to enhance metabolic stability and bioavailability.
• Material Science: Serves as a monomer or functionalizing agent in the creation of specialty polymers and advanced organic electronic materials.
• Chemical Synthesis: Acts as a versatile building block for constructing complex heterocyclic compounds in medicinal and process chemistry.
• Life Science Research: Employed in biochemical research as a probe or labeled compound for studying biological pathways and mechanisms.

Basic Information

Product Name	4,6-Difluoro-1-Methyl-1H-Indole
CAS No.	1106112-57-5
Molecular Formula	C9H7F2N
Molecular Weight	167.16 g/mol
Synonyms	1-Methyl-4,6-difluoro-1H-indole; 4,6-Difluoro-1-methylindole; 1H-Indole, 4,6-difluoro-1-methyl-; 4,6-Difluoro-1-methyl-1H-indole; 1-Methyl-4,6-difluoroindole
EINECS	Contact for details

Quality Control

Our 4,6-Difluoro-1-Methyl-1H-Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The product is light-sensitive and should be stored away from light. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.