Description

6-((Trimethylsilyl)Ethynyl)Isoquinoline is a specialized organosilicon building block featuring a trimethylsilyl-protected alkyne group fused to an isoquinoline heterocycle. This compound is valued for its role as a key synthetic intermediate in advanced organic and medicinal chemistry, enabling the construction of complex molecular architectures. It is primarily sought by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries for applications in cross-coupling reactions and the development of novel active compounds.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel drug candidates, particularly for targeted therapies.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products.
• Material Science: Serves as a precursor for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Cross-Coupling Reactions: The protected alkyne moiety is ideal for Sonogashira and other palladium-catalyzed coupling reactions to form conjugated systems.
• Ligand Synthesis: Utilized in the preparation of complex ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Acts as a scaffold for creating fluorescent or bioactive probes for biological target identification.

Basic Information

Product Name	6-((Trimethylsilyl)Ethynyl)Isoquinoline
CAS No.	1105710-05-1
Molecular Formula	C₁₅H₁₇NSi
Molecular Weight	239.39 g/mol
Synonyms	6-((Trimethylsilyl)ethynyl)isoquinoline; 6-(2-Trimethylsilylethynyl)isoquinoline; 6-(Trimethylsilylethynyl)isoquinoline; Isoquinoline, 6-[(trimethylsilyl)ethynyl]-; 6-Ethynyl-2-(trimethylsilyl)isoquinoline (possible isomer); TMS-Protected 6-Ethynylisoquinoline
EINECS	Contact for details

Quality Control

Our 6-((Trimethylsilyl)Ethynyl)Isoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.