Description

5-(Tetrahydro-2H-Pyran-4-Yloxy)Pyridine-3-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. Its core value lies in its functionalized pyridine and protected boronic ester groups, which are essential for modern cross-coupling reactions like Suzuki-Miyaura. This compound is critically needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling: Serves as a crucial boron-containing coupling partner for forming carbon-carbon bonds between aromatic and heteroaromatic systems.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring complex heterocyclic cores.
• Material Science Research: Employed in the creation of organic electronic materials, such as ligands for OLEDs and conductive polymers.
• Chemical Biology & Probe Development: Utilized for synthesizing molecular probes and tool compounds for target identification and validation in drug discovery.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	5-(Tetrahydro-2H-Pyran-4-Yloxy)Pyridine-3-Boronic Acid Pinacol Ester
CAS No.	1105663-72-6
Molecular Formula	C16H24BNO4
Molecular Weight	305.18 g/mol
Synonyms	5-(Tetrahydro-2H-pyran-4-yloxy)-3-pyridineboronic acid pinacol ester; 5-(Oxan-4-yloxy)pyridine-3-boronic acid pinacol ester; 3-Pyridineboronic acid, 5-[(tetrahydro-2H-pyran-4-yl)oxy]-, 1,1-dimethylethyl ester; 5-(Tetrahydropyran-4-yloxy)pyridin-3-ylboronic acid pinacol ester; 1105663-72-6; THP-protected pyridine boronic ester.
EINECS	Contact for details

Quality Control

Our 5-(Tetrahydro-2H-Pyran-4-Yloxy)Pyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with full analytical data are provided to guarantee compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.