Description

5-(3-Nitrophenyl)-1-[4-(Trifluoromethoxy)Phenyl]-1H-Imidazole-2-Thiol is a specialized heterocyclic organic compound featuring a nitro-substituted phenyl ring and a trifluoromethoxy phenyl group, making it a valuable intermediate for advanced synthesis. This compound is crucial for research and development in medicinal chemistry, particularly for creating novel active pharmaceutical ingredients (APIs) with targeted properties. It is primarily sought by pharmaceutical R&D laboratories, agrochemical manufacturers, and fine chemical producers for developing new therapeutic agents and high-performance materials.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of potential drug candidates, especially for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its unique imidazole-thiol and aromatic substitution pattern for bioactivity.
• Material Science: Acts as a precursor for functionalized polymers, liquid crystals, or organic electronic materials due to its rigid, multi-aromatic structure.
• Chemical Biology: Employed as a probe or linker in bioconjugation chemistry and proteomics research to study enzyme interactions.
• Custom Synthesis: Provides a versatile scaffold for contract research organizations (CROs) and fine chemical companies performing bespoke synthesis for clients.

Basic Information

Product Name	5-(3-Nitrophenyl)-1-[4-(Trifluoromethoxy)Phenyl]-1H-Imidazole-2-Thiol
CAS No.	1105189-27-2
Molecular Formula	C₁₆H₁₀F₃N₃O₃S
Molecular Weight	381.33 g/mol
Synonyms	5-(3-Nitrophenyl)-1-[4-(trifluoromethoxy)phenyl]-1H-imidazole-2-thiol; 1H-Imidazole-2-thiol, 5-(3-nitrophenyl)-1-[4-(trifluoromethoxy)phenyl]-; 2-Mercapto-5-(3-nitrophenyl)-1-[4-(trifluoromethoxy)phenyl]imidazole; 2-Thiol-5-(3-nitrophenyl)-1-[4-(trifluoromethoxy)phenyl]imidazole; 1105189-27-2; 5-(3-Nitrophenyl)-1-(4-trifluoromethoxyphenyl)-1H-imidazole-2-thiol
EINECS	Contact for details

Quality Control

Our production of 5-(3-Nitrophenyl)-1-[4-(Trifluoromethoxy)Phenyl]-1H-Imidazole-2-Thiol adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.