Description

1-(4-Fluorophenyl)-5-(4-Methylphenyl)-1H-Imidazole-2-Thiol is a high-purity, functionalized imidazole derivative of significant interest in advanced organic synthesis. This compound serves as a versatile and critical building block for the development of novel active pharmaceutical ingredients (APIs) and specialty chemicals. It is primarily sought by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors for creating molecules with tailored biological or physical properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting enzymes or receptors where the imidazole-thiol pharmacophore is relevant.
• Agrochemical Research: Used in developing novel fungicides, herbicides, or plant growth regulators, leveraging its heterocyclic core for bioactivity.
• Material Science: Acts as a monomer or functional additive in the production of specialty polymers, ligands for catalysis, or advanced organic electronic materials.
• Chemical Synthesis: Serves as a versatile scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies and library synthesis for high-throughput screening.
• Bioconjugation & Probe Development: The thiol group allows for selective conjugation, making it useful for creating biochemical probes, diagnostic agents, or targeted delivery systems.

Basic Information

Product Name	1-(4-Fluorophenyl)-5-(4-Methylphenyl)-1H-Imidazole-2-Thiol
CAS No.	1105189-09-0
Molecular Formula	C₁₆H₁₃FN₂S
Molecular Weight	284.35 g/mol
Synonyms	1-(4-Fluorophenyl)-5-(p-tolyl)-1H-imidazole-2-thiol; 2-Mercapto-1-(4-fluorophenyl)-5-(4-methylphenyl)-1H-imidazole; 5-(4-Methylphenyl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol; CAS 1105189-09-0; 1H-Imidazole-2-thiol, 1-(4-fluorophenyl)-5-(4-methylphenyl)-; 2-Thiol-1-(4-fluorophenyl)-5-(4-methylphenyl)imidazole
EINECS	Contact for details

Quality Control

Our 1-(4-Fluorophenyl)-5-(4-Methylphenyl)-1H-Imidazole-2-Thiol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere for long-term storage or when opening the primary container to maximize shelf life.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.