Description

1-tert-Butyl 3-Methyl 5-Bromo-1H-Indole-1,3-Dicarboxylate is a high-purity, synthetically valuable brominated indole derivative. This compound serves as a critical advanced pharmaceutical intermediate and versatile building block for complex organic synthesis. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical, agrochemical, and material science industries for constructing novel molecules and exploring structure-activity relationships.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting neurological and oncological pathways.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products, leveraging the indole scaffold's bioactivity.
• Organic Synthesis: A versatile precursor for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) due to the reactive bromine substituent.
• Material Science: Potential monomer or functionalizing agent for creating specialty polymers and organic electronic materials.
• Chemical Biology: Used as a probe or labeled compound in biochemical research and assay development.
• Academic & Contract Research: Essential reagent for medicinal chemistry programs and synthetic methodology research in university and CRO laboratories.

Basic Information

Item	Details
Product Name	1-tert-Butyl 3-Methyl 5-Bromo-1H-Indole-1,3-Dicarboxylate
CAS No.	1100052-64-9
Molecular Formula	C15H16BrNO4
Molecular Weight	354.20 g/mol
Synonyms	5-Bromo-1H-indole-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester; 5-Bromo-1-(tert-butoxycarbonyl)-3-(methoxycarbonyl)-1H-indole; 5-Bromo-1-Boc-3-methyl indole-1,3-dicarboxylate; 5-Bromo-1-N-Boc-3-COOMe indole; tert-Butyl 5-bromo-3-(methoxycarbonyl)-1H-indole-1-carboxylate; 5-Bromoindole-1,3-dicarboxylic acid 1-tert-butyl 3-methyl ester; Boc-5-Bromo-3-methoxycarbonylindole
EINECS	Contact for details

Quality Control

Our 1-tert-Butyl 3-Methyl 5-Bromo-1H-Indole-1,3-Dicarboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong alkalis and incompatible materials. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.