Description

1-(6-Amino-7-Chloro-3,4-Dihydroisoquinolin-2(1H)-Yl)-2,2,2-Trifluoroethanone is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoroacetylated dihydroisoquinoline structure. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with enhanced metabolic stability and bioavailability. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of central nervous system (CNS) agents, kinase inhibitors, and other therapeutic small molecules. The CAS number for this compound is 1097922-04-7.

Application

This specialized intermediate serves as a key precursor in sophisticated organic synthesis. Its primary applications include:

• Pharmaceutical Research & Development: As a crucial scaffold for synthesizing novel bioactive molecules targeting various disease pathways.
• Medicinal Chemistry: Used in the design and construction of complex heterocyclic compounds, particularly for CNS and oncology drug discovery programs.
• Chemical Biology: Employed as a probe or labeling agent due to the reactive amino and carbonyl functional groups.
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and optimization of active pharmaceutical ingredient (API) manufacturing routes.
• Academic Research: Utilized in universities and institutes for studying structure-activity relationships (SAR) and novel synthetic methodologies.

Basic Information

Product Name	1-(6-Amino-7-Chloro-3,4-Dihydroisoquinolin-2(1H)-Yl)-2,2,2-Trifluoroethanone
CAS No.	1097922-04-7
Molecular Formula	C₁₁H₉ClF₃N₂O
Molecular Weight	277.65 g/mol
Synonyms	2,2,2-Trifluoro-1-(6-amino-7-chloro-3,4-dihydro-2(1H)-isoquinolinyl)ethanone; 1-(6-Amino-7-chloro-3,4-dihydro-2(1H)-isoquinolinyl)-2,2,2-trifluoroethanone; 6-Amino-7-chloro-2-(2,2,2-trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline; 1097922-04-7; 7-Chloro-6-amino-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline; TFADHIQ; Trifluoroacetyl Dihydroisoquinoline Intermediate
EINECS	Contact for details

Quality Control

Our 1-(6-Amino-7-Chloro-3,4-Dihydroisoquinolin-2(1H)-Yl)-2,2,2-Trifluoroethanone is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We can support development with custom purity grades and analytical data packages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) in a desiccator for long-term storage to prevent moisture absorption. Recommended storage temperature is 2-8°C for prolonged stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.