Description

1-(7-Chloro-6-Nitro-3,4-Dihydroisoquinolin-2(1H)-Yl)-2,2,2-Trifluoroethanone is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoroacetylated isoquinoline core structure. This compound is critical for enabling complex synthetic pathways in modern drug discovery, particularly for the development of novel bioactive molecules. It is primarily utilized by research institutions and pharmaceutical manufacturers focused on creating new therapeutic agents, especially in the areas of central nervous system (CNS) and oncology research.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug candidates, particularly those targeting neurological disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel therapeutic targets.
• Active Pharmaceutical Ingredient (API) Development: A crucial precursor in the multi-step synthesis of potential new active pharmaceutical ingredients.
• Chemical Biology Probes: Employed in the development of specialized chemical probes for studying enzyme function and biological pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.

Basic Information

Product Name	1-(7-Chloro-6-Nitro-3,4-Dihydroisoquinolin-2(1H)-Yl)-2,2,2-Trifluoroethanone
CAS No.	1097920-65-4
Molecular Formula	C₁₁H₇ClF₃N₂O₃
Molecular Weight	307.64 g/mol
Synonyms	2,2,2-Trifluoro-1-(7-chloro-6-nitro-1,2,3,4-tetrahydroisoquinolin-2-yl)ethan-1-one; 1-(7-Chloro-6-nitro-3,4-dihydro-2(1H)-isoquinolinyl)-2,2,2-trifluoroethanone; 2-(Trifluoroacetyl)-7-chloro-6-nitro-1,2,3,4-tetrahydroisoquinoline; 7-Chloro-6-nitro-2-(2,2,2-trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline; 1097920-65-4
EINECS	Contact for details

Quality Control

Our 1-(7-Chloro-6-Nitro-3,4-Dihydroisoquinolin-2(1H)-Yl)-2,2,2-Trifluoroethanone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP (current Good Manufacturing Practice) standards where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.