Description

1-(7-Chloro-3,4-Dihydroisoquinolin-2(1H)-Yl)-2,2,2-Trifluoroethanone is a high-purity trifluoroacetylated isoquinoline derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure makes it a valuable intermediate for the development of novel pharmaceutical compounds and agrochemicals. This product is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce the trifluoroacetyl pharmacophore into complex molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science: Building block for creating specialty polymers and advanced organic materials with unique electronic or optical properties.
• Chemical Biology: Employed as a probe or labeling reagent in medicinal chemistry and biochemical research due to its reactive ketone functionality.
• Academic & Contract Research: Serves as a specialized reagent for methodological development and novel compound library synthesis in academic and CRO settings.

Basic Information

Product Name	1-(7-Chloro-3,4-Dihydroisoquinolin-2(1H)-Yl)-2,2,2-Trifluoroethanone
CAS No.	1097920-64-3
Molecular Formula	C11H9ClF3NO
Molecular Weight	263.64 g/mol
Synonyms	2,2,2-Trifluoro-1-(7-chloro-1,2,3,4-tetrahydroisoquinolin-2-yl)ethanone; 1-(7-Chloro-3,4-dihydro-2(1H)-isoquinolinyl)-2,2,2-trifluoroethanone; 7-Chloro-2-(2,2,2-trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline; N-(Trifluoroacetyl)-7-chloro-1,2,3,4-tetrahydroisoquinoline; 7-Chloro-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline; 1097920-64-3; TFATQ-C7
EINECS	Contact for details

Quality Control

Our 1-(7-Chloro-3,4-Dihydroisoquinolin-2(1H)-Yl)-2,2,2-Trifluoroethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for your most demanding applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.