Description

6-(Methylsulfonyl)-1,2,3,4-Tetrahydroisoquinoline is a high-purity, advanced pharmaceutical intermediate characterized by its sulfonyl-substituted tetrahydroisoquinoline core structure. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of central nervous system (CNS) agents, kinase inhibitors, and other therapeutic small molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing libraries of compounds in drug discovery programs targeting various disease pathways.
• CNS Drug Development: Used in the synthesis of potential therapeutics for neurological disorders due to the privileged tetrahydroisoquinoline structure.
• Kinase Inhibitor Synthesis: Employed as a building block for creating molecules designed to modulate kinase activity in oncology and inflammatory diseases.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying enzyme function and cellular signaling mechanisms.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.

Basic Information

Product Name	6-(Methylsulfonyl)-1,2,3,4-Tetrahydroisoquinoline
CAS No.	1095751-03-3
Molecular Formula	C10H13NO2S
Molecular Weight	211.28 g/mol
Synonyms	6-(Methylsulfonyl)-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-6-(methylsulfonyl)isoquinoline; 6-Methanesulfonyl-1,2,3,4-tetrahydroisoquinoline; 6-(Methylsulfonyl)THIQ; 6-Mesyl-THIQ; MS-THIQ; 1095751-03-3
EINECS	Contact for details

Quality Control

Our 6-(Methylsulfonyl)-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC, GC, NMR, and MS. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.