Description

4-[3,4-Dihydro-2(1H)-Isoquinolinyl]-3-Methylaniline is a high-purity, advanced pharmaceutical intermediate characterized by its unique tetrahydroisoquinoline-aniline hybrid structure. This compound is of significant commercial value for its role as a critical building block in the synthesis of complex bioactive molecules, particularly in central nervous system (CNS) and cardiovascular research. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in developing novel therapeutic agents and proprietary chemical libraries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates targeting neurological receptors and enzymes.
• Chemical Biology Research: Used in the design and construction of molecular probes and tool compounds for studying biological pathways.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization programs.
• Contract Manufacturing: Supplied to CDMOs for the scale-up and cGMP production of active pharmaceutical ingredients (APIs).
• Academic Research: Employed in university and institutional labs for fundamental research in organic synthesis and heterocyclic chemistry.
• Library Synthesis: A valuable component for generating diverse compound libraries for high-throughput screening (HTS).

Basic Information

Product Name	4-[3,4-Dihydro-2(1H)-Isoquinolinyl]-3-Methylaniline
CAS No.	1094746-56-1
Molecular Formula	C16H18N2
Molecular Weight	238.33 g/mol
Synonyms	3-Methyl-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)aniline; 4-(3,4-Dihydro-1H-isoquinolin-2-yl)-3-methylaniline; 3-Methyl-4-(3,4-dihydro-1H-isoquinolin-2-yl)benzenamine; 4-(1,2,3,4-Tetrahydroisoquinolin-2-yl)-3-methylaniline; 2-(2-Amino-6-methylphenyl)-1,2,3,4-tetrahydroisoquinoline; 4-(1,2,3,4-Tetrahydro-2-isoquinolinyl)-3-methylbenzenamine
EINECS	Contact for details

Quality Control

Our 4-[3,4-Dihydro-2(1H)-Isoquinolinyl]-3-Methylaniline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity, purity, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material produced to meet relevant ICH guidelines and customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.