Description

1-(Bromomethyl)-3-(2,2,2-trifluoroethoxy)benzene is a specialized aromatic building block featuring both a reactive benzyl bromide group and a trifluoroethoxy substituent. This unique bifunctional structure makes it a critical intermediate for synthesizing advanced molecules in pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists working on novel active ingredients, particularly those requiring the introduction of fluorine-containing motifs for enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the trifluoroethoxy group can improve lipophilicity and target binding.
• Ligand and Catalyst Development: Serves as a precursor for creating sophisticated ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of monomers for specialty polymers and liquid crystals, imparting unique electronic and surface properties.
• Fluorine Chemistry: A valuable reagent for introducing the 2,2,2-trifluoroethoxy moiety into complex molecular architectures.
• Chemical Biology Probes: Useful for tagging and modifying biomolecules in proteomics and diagnostic assay development.

Basic Information

Product Name	1-(Bromomethyl)-3-(2,2,2-Trifluoroethoxy)Benzene
CAS No.	1094438-85-3
Molecular Formula	C9H8BrF3O
Molecular Weight	269.06 g/mol
Synonyms	3-(2,2,2-Trifluoroethoxy)benzyl Bromide; m-(2,2,2-Trifluoroethoxy)benzyl Bromide; 1-(Bromomethyl)-3-(2,2,2-trifluoroethoxy)benzene; α-Bromo-3-(2,2,2-trifluoroethoxy)toluene; (3-(2,2,2-Trifluoroethoxyphenyl)methyl Bromide; Benzene, 1-(bromomethyl)-3-(2,2,2-trifluoroethoxy)-
EINECS	Contact for details

Quality Control

Our production of 1-(Bromomethyl)-3-(2,2,2-trifluoroethoxy)benzene adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is fully characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.