Description

3-(4-Fluorophenyl)Thiophene-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its distinct thiophene-carboxylic acid scaffold substituted with a fluorophenyl group. This compound matters for its critical role as a versatile building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. Pharmaceutical R&D and fine chemical synthesis companies need it to develop next-generation drugs, leveraging its fluorine atom for enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs) targeting central nervous system (CNS) disorders, anti-inflammatory agents, and oncology therapeutics.
• Agrochemical Research: Used in the development of advanced fungicides and herbicides, where the fluorine-thiophene moiety can contribute to improved efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of specialty polymers and organic electronic materials, such as conductive polymers or OLED components.
• Chemical Biology & Proteomics: Employed as a scaffold or linker in the design of molecular probes, enzyme inhibitors, and other tools for biochemical research and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical and CDMO (Contract Development and Manufacturing Organization) facilities.

Basic Information

Product Name	3-(4-Fluorophenyl)Thiophene-2-Carboxylic Acid
CAS No.	1094325-89-9
Molecular Formula	C11H7FO2S
Molecular Weight	222.24 g/mol
Synonyms	2-Thiophenecarboxylic acid, 3-(4-fluorophenyl)-; 3-(p-Fluorophenyl)thiophene-2-carboxylic acid; 3-(4-Fluorophenyl)-2-thiophenecarboxylic acid; 1094325-89-9; 3-(4-Fluorophenyl)thiophene-2-carboxylate; 4-Fluoro-3-thiophen-2-ylbenzoic acid (common misnomer); 3-(4-Fluorophenyl)-2-carboxythiophene
EINECS	Contact for details

Quality Control

Our 3-(4-Fluorophenyl)Thiophene-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D and commercial synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, and we support audits and regulatory documentation as needed.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect this light-sensitive material from moisture and atmospheric contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.