Description

(S)-Naproxen-D3 is a deuterium-labeled isotopologue of the non-steroidal anti-inflammatory drug (NSAID) (S)-Naproxen, where three hydrogen atoms are replaced by deuterium. This compound is a critical internal standard for the precise and accurate quantification of naproxen in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is an essential tool for pharmaceutical research and development, clinical pharmacology, and bioanalytical laboratories requiring high-fidelity data for pharmacokinetic, metabolic, and bioequivalence studies.

Application

• Internal Standard for Bioanalysis: Primary use as a stable isotope-labeled internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the quantification of naproxen in plasma, serum, and urine.
• Pharmacokinetic & Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Bioequivalence Testing: Critical for ensuring analytical method accuracy when comparing generic and brand-name drug formulations.
• Forensic & Doping Control Analysis: Used in confirmatory testing for the presence of naproxen in forensic toxicology and anti-doping programs.
• Method Development & Validation: Serves as a reference compound for developing and validating robust, GLP-compliant analytical methods.
• Metabolite Identification: Aids in distinguishing drug-derived metabolites from endogenous compounds in mass spectrometry-based metabolite profiling.

Basic Information

Product Name	(S)-Naproxen-D3
CAS No.	1094102-82-5
Molecular Formula	C14H11D3O3
Molecular Weight	233.28 g/mol
Synonyms	(S)-2-(6-Methoxy-2-naphthyl)propionic-3,3,3-d3 Acid; (+)-(S)-2-(6-Methoxynaphthalen-2-yl)propionic-3,3,3-d3 Acid; Deuterated (S)-Naproxen; [3,3,3-2H3]-(S)-Naproxen; (S)-Naproxen Methyl-d3; (S)-Naproxen-d3; L-Naproxen-d3; Dexnaproxen-d3
EINECS	Contact for details

Quality Control

Our (S)-Naproxen-D3 is manufactured under strict quality control protocols to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic methods, including NMR, HPLC, and Mass Spectrometry, to confirm identity, chemical purity, and deuterium incorporation. Certificates of Analysis (COA) detailing lot-specific results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the material at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Specific Rotation	+60.0° to +66.0° (c=1, CHCl3)
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.