Description

Afoxolaner is a potent isoxazoline-class ectoparasiticide widely recognized for its high efficacy and long-lasting action. This compound is a critical active pharmaceutical ingredient (API) valued for its excellent safety profile and targeted mechanism of action against key pests. It is primarily utilized by manufacturers in the animal health and veterinary pharmaceutical industries for the formulation of next-generation parasiticides.

Application

• Veterinary Pharmaceutical Formulations: Primary active ingredient in oral and topical parasiticides for companion animals, particularly dogs and cats.
• Flea and Tick Control Products: Formulated into chewable tablets, spot-on solutions, and collars for effective, long-term protection against infestations.
• Animal Health Preventatives: Used in products designed to prevent and treat ectoparasite infestations, contributing to animal welfare and comfort.
• Active Pharmaceutical Ingredient (API): Supplied to GMP-compliant facilities for the synthesis of finished veterinary dosage forms.
• Research & Development: Serves as a reference standard and key intermediate in the development of new parasiticidal agents and combination therapies.

Basic Information

Product Name	Afoxolaner
CAS No.	1093861-60-9
Molecular Formula	C26H17ClF3N3O3
Molecular Weight	511.88 g/mol
Synonyms	Afoxolaner; 4-[5-[3-Chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-methyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]benzamide; N-[2-Oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-methylbenzamide; NexGard® (branded product); ISOXAZOLINE-14; AFOXOLANER (USAN)
EINECS	Contact for details

Quality Control

Our Afoxolaner is manufactured under strict quality management systems to ensure it meets the high standards required for pharmaceutical use. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC. A Certificate of Analysis (COA) is provided with every shipment, detailing compliance with agreed specifications. We support compliance with GMP, ICH Q7, and relevant veterinary pharmacopoeia guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability and prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.