Description

1H-Pyrrolo[2,3-B]Pyridine-1-Carboxylic Acid, 3-Iodo-5-(1-Methyl-1H-Pyrazol-4-Yl)-, 1,1-Dimethylethyl Ester is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound is critical for medicinal chemistry research and development, serving as a key intermediate in the synthesis of novel pharmaceutical candidates. It is primarily utilized by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of kinase inhibitors and other targeted therapeutic agents.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies due to its versatile pyrrolopyridine core.
• Agrochemical Development: Serves as a precursor in the creation of new crop protection agents and pesticides.
• Chemical Biology Probes: Employed in the development of molecular probes for studying biological pathways and target engagement.
• Material Science: Potential intermediate for creating advanced organic electronic materials or ligands for catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific novel chemical entities (NCEs).

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-1-Carboxylic Acid, 3-Iodo-5-(1-Methyl-1H-Pyrazol-4-Yl)-, 1,1-Dimethylethyl Ester
CAS No.	1093676-94-8
Molecular Formula	C16H17IN4O2
Molecular Weight	424.24 g/mol
Synonyms	tert-Butyl 3-iodo-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-iodo-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine; 3-Iodo-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester; Boc-Protected 3-Iodo-5-(1-methylpyrazol-4-yl)-7-azaindole; 1-Boc-3-iodo-5-(1-methyl-1H-pyrazol-4-yl)-7-azaindole
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine-1-Carboxylic Acid, 3-Iodo-5-(1-Methyl-1H-Pyrazol-4-Yl)-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material suitable for use under cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity. Keep container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.