Description

2-Amino-5-Chloropyridine--D3 is a deuterium-labeled analog of 2-amino-5-chloropyridine, a valuable building block in synthetic organic chemistry. This isotopically labeled compound is essential for creating internal standards used in quantitative mass spectrometry, ensuring high accuracy in analytical measurements. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry sectors for drug metabolism and pharmacokinetics (DMPK) studies, environmental analysis, and the development of novel chemical entities.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference standard for the precise quantification of its non-deuterated counterpart in complex biological matrices like plasma, urine, and tissue homogenates.
• Drug Metabolism Studies (DMPK): Used in pharmaceutical R&D to track and quantify drug metabolites, enabling a clearer understanding of absorption, distribution, metabolism, and excretion (ADME) profiles.
• Pharmacokinetic Research: Facilitates accurate measurement of drug concentration over time in preclinical and clinical studies, supporting regulatory submissions.
• Agrochemical Analysis: Employed in the development and environmental monitoring of pesticides and herbicides that utilize the 2-amino-5-chloropyridine moiety.
• Isotope Dilution Mass Spectrometry (IDMS): A key component in this high-precision analytical technique for achieving definitive measurements in forensic, clinical, and environmental testing.
• Synthetic Intermediate: Acts as a deuterated precursor in the synthesis of more complex labeled compounds for research and diagnostic applications.

Basic Information

Product Name	2-Amino-5-Chloropyridine--D3
CAS No.	1093384-99-6
Molecular Formula	C5H2D3ClN2
Molecular Weight	130.58 g/mol (approx.)
Synonyms	2-Amino-5-chloro(2H3)pyridine; 5-Chloro-2-pyridinamine-d3; 2-Amino-5-chloropyridine (amino-d3); 5-Chloro-2-aminopyridine-d3; 2-Pyridinamine, 5-chloro-, 2,6,6-d3-; Deuterated 2-Amino-5-chloropyridine; 2-Amino-5-chloro-d3-pyridine; 5-Chloro-2-aminopyridine (2,6,6-d3)
EINECS	Contact for details

Quality Control

Our 2-Amino-5-Chloropyridine--D3 is manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic purity (D-enrichment), chemical purity, and identity confirmation. We adhere to relevant industry standards for high-purity reference materials, and custom specifications can be developed to meet specific research or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.