Description

5,8-Difluoro-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is a high-purity, fluorinated heterocyclic building block essential for advanced organic synthesis. This compound is valued for its role as a key intermediate in the development of novel pharmaceutical candidates, particularly in medicinal chemistry research. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to the isoquinoline scaffold and fluorine substituents.
• Agrochemical Synthesis: Serves as a precursor in the development of new herbicides, fungicides, and pesticides with enhanced biological activity and stability.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Material Science: Potential intermediate for creating advanced organic materials, such as ligands for catalysts or components in organic electronics.

Basic Information

Product Name	5,8-Difluoro-1,2,3,4-Tetrahydroisoquinoline Hydrochloride
CAS No.	1093064-83-5
Molecular Formula	C9H8F2N.HCl
Molecular Weight	203.62 g/mol (Free base: 167.16 g/mol)
Synonyms	5,8-Difluoro-1,2,3,4-tetrahydroisoquinoline HCl; 5,8-Difluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride; 1,2,3,4-Tetrahydro-5,8-difluoro-isoquinoline hydrochloride; 5,8-Difluoro-3,4-dihydro-1H-isoquinoline hydrochloride; 5,8-Difluoro-1,2,3,4-tetrahydroisoquinoline monohydrochloride
EINECS	Contact for details

Quality Control

Our 5,8-Difluoro-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.