Description

3-Methyl-L-Valine-D9 Hydrochloride is a high-purity, isotopically labeled derivative of the non-proteinogenic amino acid 3-methylvaline, specifically designed for advanced research and analytical applications. Its deuterium-labeled structure makes it an indispensable internal standard for precise quantification using mass spectrometry, ensuring superior accuracy and reproducibility in complex analyses. This compound is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and agrochemical sectors for drug metabolism studies, proteomics, and stable isotope labeling.

Application

• Mass Spectrometry Internal Standard: Serves as a critical reference compound for the accurate quantification of 3-methylvaline and related metabolites in biological matrices via LC-MS/MS and GC-MS.
• Pharmaceutical Research & Development: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies, drug metabolism and disposition (DMPK) research, and biomarker discovery.
• Proteomics and Metabolomics: Enables stable isotope labeling for the relative and absolute quantification of peptides, proteins, and small molecule metabolites.
• Clinical Diagnostics: Potential use in developing high-precision diagnostic assays for metabolic disorders.
• Isotope Tracer Studies: Applied in biochemical pathway analysis and flux studies to track the incorporation of amino acids.
• Quality Control & Reference Material: Acts as a certified reference material (CRM) for calibrating analytical instruments and validating methods in regulatory environments.

Basic Information

Product Name	3-Methyl-L-Valine-D9 Hydrochloride
CAS No.	1092540-48-1
Molecular Formula	C7H4D9ClNO2
Molecular Weight	Contact for details
Synonyms	(2S)-2-Amino-3-methyl-D9-butanoic acid hydrochloride; L-3-Methylvaline-D9 HCl; (2S)-2-Azaniumyl-3-methyl-D9-butanoate chloride; 3-Methyl-D9-L-valine hydrochloride; Deuterated 3-Methyl-L-valine HCl; 3-Methyl-2-aminobutanoic-3,4,4,4-D4,5,5,5-D4,1-D acid hydrochloride; Isotopically labeled 3-methylvaline HCl
EINECS	Contact for details

Quality Control

Our 3-Methyl-L-Valine-D9 Hydrochloride is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (atom % D), chemical purity (by HPLC), chiral purity, and residual solvent content. We adhere to relevant industry standards for high-purity reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (atom % D)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.