Description

2-(Trifluoromethoxy)-5-Fluorobenzyl Bromide is a high-purity, multi-functional benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic incorporation of both fluorine and trifluoromethoxy substituents, which are essential for modulating the physicochemical and biological properties of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) agents, anti-inflammatory drugs, and antiviral compounds.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance metabolic stability and membrane permeability.
• Ligand & Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of novel fluorinated polymers, liquid crystals, and electronic materials with unique dielectric properties.
• PET Radiochemistry: Potential precursor for the synthesis of fluorine-18 labeled tracers used in Positron Emission Tomography (PET) imaging.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific fluorinated benzyl motifs.

Basic Information

Product Name	2-(Trifluoromethoxy)-5-Fluorobenzyl Bromide
CAS No.	1092460-88-2
Molecular Formula	C8H5BrF4O
Molecular Weight	273.03 g/mol
Synonyms	5-Fluoro-2-(trifluoromethoxy)benzyl bromide; 1-(Bromomethyl)-5-fluoro-2-(trifluoromethoxy)benzene; α-Bromo-5-fluoro-2-(trifluoromethoxy)toluene; (5-Fluoro-2-(trifluoromethoxy)phenyl)methyl bromide; 2-Trifluoromethoxy-5-fluorobenzyl bromide
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethoxy)-5-Fluorobenzyl Bromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and lot-to-lot consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.