Description

(1S,2S)-2-[(4R,11Bs)-3,5-Dihydro-4H-Dinaphtho[2,1-C:1',2'-E]Phosphepin-4-Yl]-1,2-Diphenylethanamine, Min. 97% is a high-purity, chiral phosphine-amine hybrid ligand, a critical component in advanced asymmetric catalysis. Its value lies in enabling highly selective and efficient synthetic routes, which are essential for producing complex, single-enantiomer molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the development of novel active ingredients and intermediates.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Cross-Coupling Catalysis: Employed in palladium- or nickel-catalyzed reactions (e.g., Suzuki, Heck, Buchwald-Hartwig) to construct complex carbon-carbon and carbon-heteroatom bonds with high selectivity.
• Pharmaceutical Process Chemistry: Used in the development and scale-up of chiral active pharmaceutical ingredients (APIs) for therapeutic agents.
• Agrochemical Synthesis: Facilitates the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical & Specialty Intermediate Manufacturing: Enables the synthesis of high-value, complex chiral molecules for flavors, fragrances, and electronic chemicals.
• Academic & Industrial Research: A valuable tool for methodology development in organic synthesis and catalysis research.

Basic Information

Product Name	(1S,2S)-2-[(4R,11Bs)-3,5-Dihydro-4H-Dinaphtho[2,1-C:1',2'-E]Phosphepin-4-Yl]-1,2-Diphenylethanamine, Min. 97%
CAS No.	1092064-02-2
Molecular Formula	C36H28NP
Molecular Weight	505.59 g/mol
Synonyms	(1S,2S)-2-((4R,11bS)-3,5-Dihydro-4H-dinaphtho[2,1-c:1',2'-e]phosphepin-4-yl)-1,2-diphenylethanamine; (S,S)-DACH-Phosphine Ligand Derivative; (1S,2S)-DPEN-Phosphepin Ligand; Josiphos-type Chiral Ligand Analog; Chiral Ferrocenylphosphine-Amine Ligand; P,N-Hybrid Ligand; Asymmetric Hydrogenation Ligand; CAS 1092064-02-2
EINECS	Contact for details

Quality Control

Every batch of our (1S,2S)-2-[(4R,11Bs)-3,5-Dihydro-4H-Dinaphtho[2,1-C:1',2'-E]Phosphepin-4-Yl]-1,2-Diphenylethanamine undergoes rigorous analytical testing to ensure it meets the stringent purity and chiral integrity standards required for asymmetric synthesis. Our quality protocols are designed to support cGMP and ISO compliant manufacturing environments. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and identity is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a dry, cool environment. This compound is sensitive to moisture and oxidation; prolonged exposure to air or elevated temperatures should be avoided.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	Min. 97.0%
Enantiomeric Excess (Chiral HPLC)	Min. 99.0% ee
Water Content (KF)	Max. 0.5%
Residue on Ignition	Max. 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.