Description

4-Bromo-5-(Difluoromethyl)-1-Methyl-1H-Pyrazole is a high-value, multi-functional pyrazole derivative serving as a critical building block in advanced organic synthesis. Its core value lies in its unique halogenated and fluorinated structure, enabling precise molecular modifications essential for developing novel compounds with targeted properties. This intermediate is particularly vital for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Agrochemical Synthesis: Used in the design and synthesis of novel herbicides, fungicides, and insecticides, leveraging the difluoromethyl group to enhance biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials due to its halogenated aromatic core.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for creating chemical probes and affinity tags to study protein function and enzyme activity.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to construct complex biaryl systems.
• Fluorine Chemistry: Acts as a valuable reagent for introducing the difluoromethyl (CF2H) group, a bioisostere for alcohols and thiols, into target molecules to improve their pharmacokinetic profiles.

Basic Information

Product Name	4-Bromo-5-(Difluoromethyl)-1-Methyl-1H-Pyrazole
CAS No.	1089212-57-6
Molecular Formula	C5H5BrF2N2
Molecular Weight	211.01 g/mol
Synonyms	1-Methyl-4-bromo-5-(difluoromethyl)-1H-pyrazole; 4-Bromo-5-difluoromethyl-1-methyl-1H-pyrazole; 1H-Pyrazole, 4-bromo-5-(difluoromethyl)-1-methyl-; 4-Bromo-1-methyl-5-(difluoromethyl)pyrazole; 1089212-57-6; 4-Bromo-5-difluoromethyl-1-methylpyrazole
EINECS	Contact for details

Quality Control

Our 4-Bromo-5-(Difluoromethyl)-1-Methyl-1H-Pyrazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.