Description

Aripiprazole-D8 (Butyl-D8) is a high-purity, deuterium-labeled internal standard essential for accurate quantitative analysis in pharmaceutical research and development. This stable isotope-labeled compound is specifically designed for use in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) applications, providing superior precision and reliability. It is a critical tool for scientists and quality control laboratories in the pharmaceutical, contract research organization (CRO), and academic sectors who require definitive analytical standards for pharmacokinetic studies, drug metabolism research, and bioanalytical method validation.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard for the precise quantification of Aripiprazole and its metabolites in biological matrices (plasma, serum, urine) using LC-MS/MS.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical research.
• Drug Metabolism Research: Used to identify and quantify metabolite profiles, aiding in the understanding of a drug's metabolic pathways.
• Method Development & Validation: Essential for developing, optimizing, and validating robust and compliant bioanalytical methods according to FDA and ICH guidelines.
• Quality Control & Impurity Profiling: Supports impurity identification and assay validation in active pharmaceutical ingredient (API) and finished product quality control.
• Forensic & Clinical Toxicology: Assists in the accurate measurement of Aripiprazole levels for therapeutic drug monitoring and forensic investigations.

Basic Information

Product Name	Aripiprazole-D8 (Butyl-D8)
CAS No.	1089115-04-7
Molecular Formula	C23H19D8Cl2N3O2
Molecular Weight	~ 452.42 g/mol
Synonyms	7-{4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy}-3,4-dihydro-2(1H)-quinolinone-d8; 7-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one-d8; Aripiprazole-d8; Aripiprazole (Butyl-d8); Deuterated Aripiprazole; Aripiprazole Internal Standard; Aripiprazole Stable Isotope
EINECS	Contact for details

Quality Control

Every batch of Aripiprazole-D8 (Butyl-D8) is manufactured and analyzed under strict quality systems. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic techniques, to ensure compliance with the high-purity standards required for analytical applications. A comprehensive Certificate of Analysis (COA) detailing isotopic purity, chemical purity, and analytical results is provided with each shipment to guarantee traceability and reliability for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.