Description

Isoquinoline-1-Carboxylic Acid Hydroxyamide is a high-purity, specialized heterocyclic building block of significant interest in medicinal chemistry and advanced organic synthesis. Its core value lies in its unique molecular scaffold, which serves as a privileged structure for developing novel pharmacologically active compounds. This product is essential for research and development scientists in the pharmaceutical, agrochemical, and fine chemical industries who are engaged in drug discovery, chemical biology, and the synthesis of complex molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly enzyme inhibitors targeting metalloproteases like histone deacetylases (HDACs).
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in oncology and neurology research programs.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes to study enzyme function and biological pathways.
• Fine Chemical Synthesis: Serves as a sophisticated building block for constructing complex heterocyclic compounds and natural product analogs.
• Agrochemical Research: Investigated as an intermediate for developing new active ingredients with herbicidal or fungicidal properties.

Basic Information

Product Name	Isoquinoline-1-Carboxylic Acid Hydroxyamide
CAS No.	1086392-60-0
Molecular Formula	C10H8N2O2
Molecular Weight	188.18 g/mol
Synonyms	1-Isoquinolinecarbohydroxamic Acid; 1-Carboxyhydroxamidoisoquinoline; Isoquinoline-1-hydroxamic Acid; 1-Hydroxycarbamoylisoquinoline; N-Hydroxyisoquinoline-1-carboxamide; 1-Isoquinolylhydroxamic Acid; HDAC Inhibitor Intermediate; Quinoline-1-carboxylic acid hydroxyamide (related)
EINECS	Contact for details

Quality Control

Our Isoquinoline-1-Carboxylic Acid Hydroxyamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.