Description

1-(1-Phenylethyl)Indolin-6-Amine is a high-purity, advanced pharmaceutical intermediate featuring a unique indoline scaffold with a chiral phenylethyl substituent. This compound is critical for the synthesis of complex bioactive molecules, offering a versatile building block for medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing novel therapeutic agents, particularly in the areas of central nervous system (CNS) and oncology drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of potential drug candidates targeting neurological disorders.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Active Pharmaceutical Ingredient (API) Development: Employed in the synthetic route development for new chemical entities (NCEs), especially those with indoline-based structures.
• Asymmetric Synthesis: Utilized in chiral synthesis due to its stereogenic center, enabling the production of enantiomerically enriched compounds.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Reference Standard: Can be provided as a high-purity analytical standard for method development and quality control in API manufacturing.

Basic Information

Product Name	1-(1-Phenylethyl)Indolin-6-Amine
CAS No.	1086392-36-0
Molecular Formula	C16H18N2
Molecular Weight	238.33 g/mol
Synonyms	6-Amino-1-(1-phenylethyl)indoline; 1-(α-Methylbenzyl)-6-aminoindoline; 1-(1-Phenylethyl)-2,3-dihydro-1H-indol-6-amine; 1-(1-Phenylethyl)-6-aminoindoline; 1H-Indol-6-amine, 2,3-dihydro-1-(1-phenylethyl)-; (R/S)-1-(1-Phenylethyl)indolin-6-amine
EINECS	Contact for details

Quality Control

Our 1-(1-Phenylethyl)Indolin-6-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via spectroscopic methods (NMR, IR, MS). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your internal specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture and air.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.